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. 2016 Aug 23;11(8):e0161199. doi: 10.1371/journal.pone.0161199

Fig 5. The effects of point mutations in the CcsA- and Syn2 A domains on product formation.

Fig 5

The chromatograms show BPCs of A. nidulans extracts expressing various single- and double mutations in the NRPS A domain as specified above the traces. EICs for niduclavin and niduporthin are highlighted in blue. A) Expression of CcsA containing single- and double point mutations (E3334S and C3388G). B) Expression of Syn2 containing single- and double point mutations (S3381E and G3435C). Only niduporthin-production by Syn2 was affected by introduction of the mutations.