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. 2016 Aug 23;11(8):e0161465. doi: 10.1371/journal.pone.0161465

Fig 1. Skin abnormalities in smsk mice.

Fig 1

(a) E18.5 smsk embryos display a shiny, tight and thickened skin phenotype with limb contractures. (b) Smsk E18.5 embryos have epidermal barrier defects as demonstrated by a toluidine dye penetration assay. (c) Histology of mutant E18.5 embryonic skin demonstrates severe hyperkeratosis with more than 16 layers of corneocytes in the SC and disorganized architecture in other epidermal layers. Bar for a and b = 2.5 mm. Bar for c = 25 μm. Epidermal layers: SB = stratum basale; SS = stratum spinosum; SG = stratum granulosum; SC = stratum corneum.