Table 2. Association of select factors with eosinophilic inflammation in any tissue on initial endoscopy in 105 children with intestinal failure.
| Eosinophilic Inflammation | |||
|---|---|---|---|
| No (n=74) | Yes (n=31) | P value** | |
| Demographics | |||
| Male Sex | 39 (53%) | 17 (55%) | 0.84 |
| Gestational Age <37 weeks (n=92) |
49 (75%) | 20 (74%) | 0.89 |
| Diagnosis* | |||
| Necrotizing enterocolitis | 24 (32%) | 11 (35%) | 0.76 |
| Gastroschisis | 19 (26%) | 3 (10%) | 0.07 |
| Ileal atresia | 5 (7%) | 4 (13%) | 0.44 |
| Jejunal atresia | 4 (5%) | 4 (13%) | 0.23 |
| Volvulus | 11 (15%) | 9 (29%) | 0.09 |
| Pseudo-obstruction | 6 (8%) | 1 (3%) | 0.67 |
| Hirschsprung's Disease |
9 (12%) | 0 (0%) | 0.06 |
| Nutrition | |||
| Amino acid-based formula | 15 (20%) | 9 (29%) | 0.33 |
| Intact protein formula | 9 (12%) | 5 (16%) | 0.55 |
| Intact protein formula + solids |
50 (68%) | 21 (68%) | 0.99 |
| PN | 43 (58%) | 19 (61%) | 0.76 |
| Labs | |||
| Peripheral absolute eosinophil count (median, IQR) (n=83) |
0.26 (0.15, 0.49) | 0.66 (0.41, 1.45) | 0.0009 |
| Other | |||
| Hematochezia | 8 (11%) | 10 (32%) | 0.01 |
| Duodenal aspirates collected | 22 (30%) | 6 (19%) | 0.27 |
| Small bowel bacterial overgrowth (n=15 among patients with duodenal aspirates collected) | 12 (55%) | 3 (50%) | 1.00 |
| Atopic disease | 41 (55%) | 16 (52%) | 0.72 |
*
Not mutually exclusive
**
Fisher exact, chi square or Wilcoxon rank sum test