. 2016 Aug 23;11(8):e0161439. doi: 10.1371/journal.pone.0161439

Table 2. GA-specific RIs of blood chemistry and hematology for preterm infants (International Unit).

			Total <37w							Classified by GA
			Total <37w							<28w							28-32w							32-37w
				LL90%CI		RI		UL90%CI			LL90%CI		RI		UL90%CI			LL90%CI		RI		UL90%CI			LL90%CI		RI		UL90%CI
Analyte	SI unit	SDR_GA	n	LL	UL	LL	UL	LL	UL	n	LL	UL	LL	UL	LL	UL	n	LL	UL	LL	UL	LL	UL	n	LL	UL	LL	UL	LL	UL
TP	g/L	1.02								113	25	30	27	48	44	52	194	33	35	34	52	51	54	1164	40	41	40	63	62	64
ALB	g/L	0.95								96	19	22	20	32	30	34	161	25	26	25	35	34	36	1052	28	28	28	40	39	40
BUN	mmol/L	0.14	1476	1.38	1.57	1.44	5.98	5.65	6.41
CRE	μmol/L	0.44								112	24.8	29.2	27.4	79.7	72.6	86.7	192	24.8	31.0	30.1	79.7	69.9	85.0	1149	35.4	37.2	36.3	85.0	81.4	87.6
T-BIL	μmol/L	0.36	1432	20.5	21.9	21.0	57.8	55.6	61.2
D-BIL	μmol/L	0.00	868	5.6	5.8	5.8	19.2	18.3	20.2
Na	mmol/L	0.40								94	128	130	129	142	141	144	162	131	133	131	142	141	143	1050	133	134	134	142	142	143
K	mmol/L	0.00	1272	3.6	3.7	3.7	6.1	6.0	6.2
CL	mmol/L	0.00	1314	100	101	101	111	111	112
Ca	mmol/L	0.18	1466	2.0	2.0	2.0	2.7	2.6	2.7
CRP	μg/L	0.14	1356	0.00	0.00	0.00	0.80	0.20	7.20
AST	IU/L	0.28	1281	15	16	16	70	65	78
ALT	IU/L	0.66								105	1	1	1	6	5	9	193	1	1	1	9	7	11	1149	2	2	2	12	11	13
LDH	IU/L	0.11	1297	238	263	245	787	742	958
ALP	IU/L	0.16	462	351	397	372	1082	1022	1152
CK	IU/L	0.44								88	22	60	45	916	583	1263	173	38	76	53	552	455	694	988	79	113	91	707	644	778
WBC	10⁹/L	0.57								102	2.55	3.87	3.04	31.0	22.5	39.2	179	2.58	4.07	3.40	19.9	16.4	23.5	1100	5.76	6.75	6.03	21.2	20.3	22.6
RBC	10¹²/L	0.59								103	2.63	2.98	2.76	4.65	4.51	4.82	178	3.20	3.41	3.28	5.07	4.91	5.27	1084	3.59	3.65	3.62	5.52	5.46	5.57
HGB	g/L	0.33	1406	125	129	127	203	201	206
HCT	/L	0.31	1408	0.37	0.38	0.38	0.60	0.60	0.61
PLT	10⁹/L	0.20	1344	107	120	114	375	367	382
NEUT	10⁹/L	0.79								46	0.17	0.81	0.64	17.0	11.7	27.6	91	0.15	0.68	0.37	9.58	7.36	12.6	490	0.93	1.54	1.19	12.7	10.7	14.3
LYMP	10⁹/L	0.30	754	1.88	2.36	2.06	9.72	9.21	10.3
MONO	10⁶/L	0.64								52	30	152	57	1623	1270	2185	118	29	110	64	1147	1005	1323	578	150	217	181	1413	1286	1523
EOS	10⁶/L	0.32	745	6	36	8	741	693	797
BASO	10⁶/L	0.10	748	1	2	2	270	241	300

TP; total protein, ALB; albumin, BUN; blood urea nitrogen, CRE; creatinine, T-BIL; total bilirubin, D-BIL; direct bilirubin, Na; sodium, K; potassium, CL; chlorine, Ca; calcium, CRP; C-reactive protein, AST; aspartate aminotransferase, ALT; alanine aminotransferase, LDH; lactate dehydrogenase, ALP; alkaline phosphatase, CK; creatine kinase, WBC; white blood cell, RBC; red blood cell, HGB; hemoglobin, HCT; hematocrit, PLT; platelet, NEUT; neutrophil, LYMP; lymphocyte, MONO; monocyte, EOS; eosinophil, BASO; basophil, GA; gestational age, RI; reference interval, LL; lower limit of the RI, UL; upper limit of the RI, CI; confidential interval (90%) of LLs and ULs were estimated by the bootstrap method. The results were excluded data of LDH, AST and CK in the infants with P20-29; Respiratory and cardiovascular disorders specific to the perinatal period, CRP with P35-39; Infections specific to the perinatal period, and K and T-Bil with P50-61; Hemorrhagic and homological disorders specific to fetus and newborn, respectively. A multivariate iterative method called latent abnormal value exclusion (LAVE) was applied to nine analytes (TP, BUN, K, LDH, ALT, WBC, CRP, HGB and HCT) which deemed to be adversely affected by hemolysis and inflammation. By use of 3-level nested ANOVA, the influence of GA on test results was expressed in terms of standard deviation (SD) ratio (SDR), as SDR_GA. SDR> = 0.4 were used as a criteria for the need of partition by the factor.