Table 2. Kinetic equilibrium constants derived from three-step models proposed.

Receptor	Ligand	Model-1			Model-2			C
		K	E	D	K	E	F
3α4:2β2	Saz-A	27	0.10	0.50	27	1.99	0.05	8.75
	TC-2559	833	0.27	0.28	836	3.59	0.08	9.15

K, E, D and F represent binding, gating, desensitized and flipping equilibrium constants respectively, as discussed in the text. Value of constant multiplier ‘C’ derived from the models is shown.