Fig 2. Couple ART and PrEP use over time.

This graph illustrates the overall distribution of ART use by HIV-1-infected partners and PrEP use by HIV-1-uninfected partners within the study partnerships, over follow-up. The proportion of couples using only PrEP for HIV-1 prevention declined over time, as HIV-1-infected participants initiated ART, as defined by the PrEP as a bridge to ART approach of the project. Through month 6, there was the greatest overlap between ART and PrEP; thereafter, couples with HIV-1 infected partners that initiated ART at or soon after enrollment begin to discontinue PrEP. The primary reason for couples using neither ART nor PrEP was missed visits, which were considered as not exposed to PrEP (since PrEP was distributed only at the study sites during the study period) nor to ART (which was assumed to have not been initiated until first reported).