Figure 2. EZO levels in infants and young children compared to adults at similar doses.

Adult mean (middle line in bar) and 95%–5% range (top and bottom of bar) EZO levels are shown, along with the levels measured in this study. Adult values at 1 and 8 hours after dosing are taken from a pharmacokinetic model fit to serum EZO levels collected during regulatory trials.²³ Adult doses of 300 mg TID (A) and 400 mg TID (B) correspond to 11.8 and 15.8 mg/kg/d, respectively (mean adult study patient weight was 76 ± 16.5 kg, n = 1,219). EZO levels measured in infants and young children, indicated by circles (red, age 6–16 months; blue, age 19 months to 6 years) were within the range observed for comparable doses in adults, and means were similar or somewhat higher than those measured in adults.