. Author manuscript; available in PMC: 2016 Aug 23.

Published in final edited form as: Crit Care Med. 2011 Jul;39(7):1749–1759. doi: 10.1097/CCM.0b013e3182190b62

Table 3.

State-3 respiration, State-4 respiration, and respiratory control ratio (RCR) in mitochondria isolated from diaphragms of control (CON), mechanically ventilated (MV), and mechanically ventilated animals treated with the mitochondrial antioxidant, SS-31 (MVSS). These data were obtained using pyruvate/malate as substrate. Units for state-3 and state-4 oxygen consumption (VO₂) are nmoles oxygen/mg protein/minute.

Parameter	Control	MV	MVSS
State-3 VO₂	235.9±10	212.4±11	193.1±9
State-4 VO₂	61.8±3	77.6±5^*	42.4±3
RCR	4.7±0.2	2.7±0.3^*	4.6±0.2
ADP/O ratio	2.1±0.2	2.3±0.2	2.3±0.2

Values are means ± SEM.

different (p<0.05) from both CON and MVSS.