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. 2016 Aug 22;213(9):1851–1864. doi: 10.1084/jem.20150514

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© 2016 Sun et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

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Figure 1. — NADPH oxidase activity and antibiotic inefficacy against coinfection. (A) Survival of C57BL/6 WT and Nox2^−/y mice infected with MRSA only. Infected mice were treated daily with the linezolid or PBS. (B–E) Survival of C57BL/6 WT (7–10 mice/group), Nox2^−/y (7–10 mice/group), p47^phox−/− mice (8–10 mice/group), and Nox2^−/− mice superchallenged with MRSA on day 7 after PR8 virus infection. Coinfected mice were treated daily with the antibiotics linezolid (B and C), gentamicin (D), or vancomycin (E). In B and C, control mice were treated daily with PBS. *, P < 0.05; **, P < 0.01; ***, P < 0.001, log-rank test. Data shown in A were combined from two independent experiments. Data shown in B–E are representative of at least two independent experiments.