Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2016 Aug 22;213(9):1851–1864. doi: 10.1084/jem.20150514

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2016 Sun et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

PMC Copyright notice

Figure 9. — Antibiotic therapy is insufficient to rescue Nox2^+/− mosaic mice from coinfection. (A–F) WT, Nox2^−/− (KO), and Nox2^+/− (Mosaic) females were infected with PR8 and 7 d later superchallenged with MRSA. At 6 dpi, lungs were analyzed for bacterial burdens (A), viral titers (B), albumin (C), protein (D), LDH activities (E), and MPO (F) in BALF. Coinfected mice were treated daily with gentamicin until 24 h before harvesting the samples. *, P < 0.05; **, P < 0.01; ***, P < 0.001, Mann Whitney test (C) or Tukey's multiple comparisons test (D–F). AU, arbitrary units. (G and H) Survival of WT, Nox2^−/− (KO), and Nox2^+/− (Mosaic) mice after superchallenge of day 7 PR8-infected mice with MRSA. **, P < 0.01; ***, P < 0.001, log-rank test. Coinfected mice were treated daily with gentamicin (G), linezolid, or PBS (H). Data shown in A–G were combined from two independent experiments. Data shown in H are representative of two independent experiments.