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. 2016 Aug 22;213(9):1881–1900. doi: 10.1084/jem.20151563

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© 2016 Chopra et al.

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Figure 4. — A human TNFR2-specific STAR2 equivalent expands human T reg cells in vitro. (A) Human CD4⁺ T cells were isolated from healthy donor PBMCs and treated with 1.67 nM TNC-scTNF(143N/145R) for 96 h. Combined data are from 16 independent experiments and show mean ± 95% confidence interval. (B) Large bowel biopsies from allo-HCT patients stained for TNFR2 (green) and Foxp3 (red); representative image from five patients. Bar, 25 µm.