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Schematic illustrations of the interaction of Grp94 or Hsp90 with NECA, Radamide, and PU-H54. Hydrogen bond interactions are denoted by dashed lines, van der Waals contacts are shown as pairs of arcs, and waters are shown as spheres. A) Grp94:NECA (PDB 1qy5). B) yeast Hsp90:Radamide (PDB 2fxs). Residues are numbered according to their human Hsp90α equivalents. C) Grp94:PU-H54 (PDB 3o2f).
