Table 4.
Sensitivity analyses for long-term associations between ADHD medication and depression in 2009.
| Analysis | Number of patients |
Number of outcomes |
Adjusted hazard ratio (95% CI) |
|---|---|---|---|
| Stimulant medication in 2006 in patients excluding those ever received atomoxetine a | 30,756 | 2278 | 0.51 (0.43–0.60) |
| Duration of stimulant medication 2006–2008 in patients excluding those ever received atomoxetine b | 30,756 | 2278 | 0.77 (0.72–0.82) |
| ADHD medication in 2006 in patients excluding those who never received medication a | 19,459 | 1223 | 0.66 (0.57–0.76) |
| Duration of ADHD medication 2006–2008 in patients excluding those who never received medication b | 19,459 | 1223 | 0.84 (0.79–0.89) |
| Duration of stimulant medication 2006–2008 using a 3-month cutoff to define treatment interval b | 38,752 | 2987 | 0.84 (0.77–0.91) |
a
The hazard ratio is the ratio of the hazard rates between those with and without ADHD medication on January 1, 2006.
b
The hazard ratio is the ratio of the hazard rates associated with one year increase in the duration of ADHD medication.