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. Author manuscript; available in PMC: 2018 Mar 1.
Published in final edited form as: Pharmacogenomics J. 2016 Feb 23;17(2):204–208. doi: 10.1038/tpj.2016.3

Figure. Effect of rs11591147 on baseline LDL-C concentrations and statin response.

Figure

Off-treatment LDL-C levels (A) and statin response (B) in carriers and non-carriers of rs11591147. The analysis was adjusted for age (at the time of the on-treatment LDL-C measurement), sex, and two primary principal components (PCs) for ancestry. In order to control for possible associations with off-treatment LDL-C level, the analysis of LDL-C response to statin was additionally adjusted for off-treatment LDL-C (natural log transformed) and the statin dose-equivalent. A p-value < 0.0045 (0.05/11) was considered statistically significant.