Figure 2.

CD57 and T-bet are upregulated, while Eomes is downregulated during NK cell maturation and KIR acquisition. Expression levels of CD57 (A,B), eomes (C,D), and T-bet (E,F) in CD56^bright or in CD56^dim CD94^neg cells according to the number of KIR (A,C,E) or licensing KIR (B,D,F) expressed. Medians are shown, and Wilcoxon matched-pairs signed rank test was used for statistical analysis, p values are indicated. As mentioned in the text, CD94^pos NK cells have been excluded from analysis because, although the results are very similar (not shown), the inclusion of CD94^pos NK cells would render the interpretation of the results more difficult.