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PI3K inhibition reverses carbachol‐induced bronchoconstriction in a dose‐dependent manner in hPCLS. Airways were preconstricted to carbachol (10−8–10−4 M) prior to dilation to LY294002, CAL‐101 or formoterol (10−11–10−5 M). Maximal airway dilation (Emax, ANOVA, P = 0.03) and AUC (P = 0.004) for each inhibitor was significantly different than formoterol‐induced dilation. Data are representative of n ≥ 5 donors, 26–33 slices per condition, with bars representing mean + SEM.
