Figure 6.

Distribution of non‐synonymous MT₁ (A) and MT₂ (B) receptor variants identified in various human populations. Positions of variants are highlighted in light brown. Typical signatures of MT receptors such as the ^3.49NRY^3.51 motif and the ^7.49NAXXY^7.53 motif are highlighted in red. Residues suspected to be directly involved in melatonin binding (S3.35 and S3.39 in MT₁ and H5.46 in both MT₁ and MT₂ receptors) are highlighted with a blue circle. The putative palmitoylation site at C314 is indicated in MT₁ receptors.