. 2016 Aug 10;173(18):2766–2779. doi: 10.1111/bph.13555

Table 2.

Effect of butyrylcholine (500 μM at the serosal side) or propionylcholine (500 μM at the serosal side) on Isc across mucosal‐submucosal or mucosal preparations of rat distal colon after repeated application to the tissue

	Butyrylcholine
	Mucosa–submucosa		Mucosa
	ΔI _sc (μEq·h⁻¹·cm⁻²)	n	ΔI _sc (μEq·h⁻¹·cm⁻²)	n
1st administration	4.34 ± 0.77^a	8	11.62 ± 1.49^a	8
2nd administration	2.94 ± 0.82^a	8	10.28 ± 1.03^a	8
3rd administration	2.49 ± 0.82^a	8	8.85 ± 0.83^a	8

	Propionylcholine
	Mucosa–submucosa		Mucosa
	ΔI _sc (μEq·h⁻¹·cm⁻²)	n	ΔI _sc (μEq·h⁻¹·cm⁻²)	n
1st administration	5.65 ± 0.65^a	7	9.69 ± 1.60^a	6
2nd administration	3.02 ± 0.55^b	7	5.87 ± 0.90^b	6
3rd administration	2.03 ± 0.40^b	7	4.17 ± 0.44^b	6

Butyrylcholine and propionylcholine, respectively, was administered three times to the same tissue, after each administration the tissue was washed three times. Values are means ± SEM and are given as difference to the baseline just before administration of the respective agonist (ΔI _sc). Statistical homogeneous groups are indicated by the same letter a, b; ANOVA followed by least‐significance difference post hoc test.