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. 2016 Aug 24;36(34):8790–8801. doi: 10.1523/JNEUROSCI.0168-16.2016

Figure 7.

Figure 7.

Defective docking of BDNF-containing and ATP-containing vesicles are rescued by Rab3a overexpression in HD astrocytes. A–D, TIRFM revealing that the docking of BDNF-containing vesicles (A, C; Student's t test; WT vs KI: WT, n = 11 cells, KI, n = 16 cells, p = 0.0043; KI vs KI+Rab3a-V5: KI, n = 16 cells; KI+Rab3a-V5, n = 8 cells, p = 0.0275) and ATP-containing vesicles (B, D; Student's t test; WT vs KI: WT, n = 16 cells; KI, n = 13 cells, p = 0.0435; KI vs KI+Rab3a-V5: KI, n = 13 cells; KI+Rab3a-V5, n = 15 cells, p = 0.0226) are compromised in KI astrocytes, which can be improved by overexpressing Rab3a. *p < 0.05, **p < 0.01. Scale bar, 10 μm.