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. 2016 Aug 24;36(34):8815–8825. doi: 10.1523/JNEUROSCI.0345-16.2016

Figure 3.

Figure 3.

Potentiation by 24(S)-HC only requires the NMDA receptor TMD. A, Exposure to 10 μm 24(S)-HC (shaded bar) potentiated whole-cell current evoked by 10 μm kainate (open bars) in an HEK cell transfected with the N1/N2B TMD chimera. B, Minimal effect of 24(S)-HC on the N1/N2B ATD+LBD chimera activated by 10 μm NMDA plus 10 μm glycine. C, Plot of current (mean ± SEM) evoked after exposure to 24(S)-HC as a fraction of control current before 24(S)-HC treatment. *, Significant difference from wild-type GluN1/2B was observed for homomeric GluK2 (Q or R) and for the N1/N2B ATD+LBD chimera, which has an unedited (Q) kainate receptor TMD but not for chimeric constructs with the NMDA receptor LBD+TMD or TMD alone (p < 0.001, ANOVA on ranks with post hoc Dunn's test).