Table 3.
Comparison of presynaptic effects evoked by different ATP congeners during recordings from POMC neurons in Arca
| Frequency (Hz) |
p | Amplitude (−pA) |
p | n | |||
|---|---|---|---|---|---|---|---|
| Control | + Agonist | Control | + Agonist | ||||
| ATP | 2.46 ± 0.72 | 11.74 ± 3.15 | 0.009 | 63.4 ± 6.5 | 74.6 ± 7.3 | 0.13 | 14 |
| ATPγS | 3.26 ± 1.17 | 5.90 ± 1.65 | 0.001 | 70.2 ± 8.2 | 74.1 ± 7.1 | 0.40 | 14 |
| BzATP | 3.69 ± 2.26 | 3.38 ± 1.96 | 0.43 | 59.4 ± 12.1 | 57.9 ± 9.0 | 0.84 | 6 |
| α,βmeATP | 1.50 ± 1.10 | 1.10 ± 0.31 | 0.39 | 48.4 ± 4.0 | 47.7 ± 5.2 | 0.81 | 7 |
aAll the putative agonists were identically applied via a local puffer positioned near the neuron that was being recorded by the whole-cell voltage-clamp method.