Figure 2.

Activation of the RE increased amphetamine-induced hyperlocomotion. A, Representation of histological placements of infusion cannulae into the RE (open circles). d-amphetamine sulfate (0.75 mg/kg, i.p.) was delivered immediately after acute microinjection of NMDA or dPBS vehicle (VEH) into the RE (both represented by dashed arrow). Baseline locomotor activity (0–30 min) and amphetamine-induced hyperlocomotion (35–90 min) were then measured. B, Pharmacological activation of RE increased total distance traveled in the 60 min postinjection period compared with controls (unpaired t test, *p < 0.05). C, Pharmacological activation of the RE increased ambulatory distance during the postinjection period (two-way repeated-measures ANOVA, Holm–Sidak post hoc, *p < 0.05). VEH, n = 13 rats; NMDA n = 8 rats. Data are represented as mean ± SEM.