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. 2016 Aug 24;6:31965. doi: 10.1038/srep31965

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Copyright © 2016, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Heatmap represents relative mRNA abundance of 3800 genes (heterochromatic and genes with low mRNA abundance have been excluded) and relative PfH3.3 occupancy in upstream, coding and downstream region throughout intraerythrocytic development. Color-scale depicts the relative mRNA abundance in relation to the sum of the RPKM values in all four stages or the relative PfH3.3 occupancy in proportion to the sum of occupancy values in all four stages (green – low, red – high). 8 groups of co-expressed genes were identified using k-means clustering. The percentage of genes belonging to each cluster is displayed next to the heatmap. Stages: ER: early rings (10 hpi), LR: late rings (20 hpi), T: trophozoites (30 hpi), S: schizonts (40 hpi).