Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2016 Aug 2;21(9):1158–1166. doi: 10.1038/mp.2016.111

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2016 The Author(s)

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/

PMC Copyright notice

pCREB expression in PBMC correlates with pCREB expression in PFC. (a) Representative blot showing expression of pCREB in PBMC and PFC in the same individuals. (b) pCREB in the PBMC is weakly correlated with pCREB expression in the PFC (P=0.19). (c) Linear regression analysis revealed that pCREB expression in PBMC correlates with pCREB expression in the PFC when the temporal interval between blood and brain sample is <3 years (P=0.035). (d, e) No correlation is observed in cognitively normal individuals between PFC pCREB and PBMC pCREB (d; P=0.52). However, a strong positive correlation exists between PFC pCREB and PBMC pCREB in the AD individuals (e; P=0.002). AD, Alzheimer's disease; CREB, cyclic-AMP response element binding protein; PBMC, peripheral blood mononuclear cells; PFC, prefrontal cortex.