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. 2016 Aug 2;21(9):1158–1166. doi: 10.1038/mp.2016.111

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Copyright © 2016 The Author(s)

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/

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CBP expression in PBMC is not related to CBP expression in the PFC. (a) Representative blot showing expression of CBP in PBMC and PFC in the same individuals (b). CBP expression in the PBMC is not correlated with expression in the PFC by a Pearson correlation (P=0.58). (c) CBP expression in PBMC drawn less than 3 years prior to death is weakly correlated with CBP expression in the PFC (P=0.20). (d, e) When the data are split into cognitively normal and AD individuals, weak negative correlations are observed between PFC CBP and PBMC CBP in cognitively normal individuals (d; P=0.22) and AD individuals (e; P=0.41). AD, Alzheimer's disease; CBP, cyclic-AMP response element-binding protein-binding protein; PBMC, peripheral blood mononuclear cells; PFC, prefrontal cortex.