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. 2016 Aug 2;21(9):1158–1166. doi: 10.1038/mp.2016.111

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Copyright © 2016 The Author(s)

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/

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PFC pCREB expression is not associated with severity of local amyloid or tau pathology. (a) Amyloid counts are higher in the superior frontal gyrus (SFG) of AD compared with cognitively normal SFG (P=0.002). (b) pCREB in the PFC is not correlated with severity of amyloid pathology in SFG by a Pearson correlation (P=0.32). (c) Tangle counts are higher in the postmortem SFG of AD compared with cognitively normal (P=0.006). (d) pCREB in the PFC is not correlated with severity of tangle pathology in the SFG by a Pearson correlation (P=0.94). AD, Alzheimer's disease; CREB, Cyclic-AMP response element-binding protein; PFC, prefrontal cortex.