Fig. 1. Cortical morphometry measures: Cortical thickness as the sum of the distances from each voxel on the grey matter (GM) tissue mantle to the GM/white matter (WM) and GM/cerebrospinal fluid (GM/CSF) tissue boundaries (a) estimated in the voxel-based imaging space and (b) mapped onto cortical surface reconstruction; (c) cross-sectional view of cortical surface reconstruction and the corresponding outer surface tightly surrounding this cortical surface; (d) sulcal depth measured from the cortical surface to the reference outer surface as in (c).