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. 2016 Aug 24;16(1):310. doi: 10.1186/s12906-016-1278-7

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — Putative mechanisms for OFE in improving insulin resistance and depression. OFE promotes the expression of adiponectin, which is an adipokine involved in insulin sensitivity and anti-depression. In addition, the neurotransmitters (5-HT and dopamine) in brain regions were also elevated by OFE, which also leads to anti-depression