Table 1.
Brain Cortex | Treatment | Neurotransmitter (ng/g brain tissue) | ||||
---|---|---|---|---|---|---|
DA | DOPAC | 5HT | 5HIAA | Norepinephrine | ||
Frontal Cortex | Control | 1277.7 ± 332.8b | 741.7 ± 115.5b | 797.3 ± 72.8a | 863.0 ± 47.2a | 409.1 ± 107.3c |
STZ-PBS | 238.4 ± 27.00.2b | 175.9 ± 55.5c | 323.3 ± 93.4c | 99.7 ± 11.5c | 685.6.9 ± 34.4b | |
STZ-Rosi | 851.5 ± 307.3b | 615.3 ± 54.2b | 594.5 ± 220.3bc | 283.7 ± 39.9b | 939.2 ± 81.8a | |
STZ-OFE | 2343.2 ± 824.4a | 1467.4 ± 136.6a | 931.1 ± 45.6a | 939.5.7 ± 59.8a | 861.33 ± 84.4a | |
Striatum | Control | 986.8 ± 73.2b | 1013.1 ± 101.6ab | 936.7 ± 93.8a | 863.0.0 ± 47.2b | 916.52 ± 49.9a |
STZ-PBS | 806.1 ± 138.3 b | 681.6 ± 61.2c | 583.1 ± 97.4b | 481.0 ± 33.9c | 613.7 ± 26.2b | |
STZ-Rosi | 1185.3 ± 423.9b | 797.6 ± 103.1bc | 613.8 ± 129.7b | 491.7 ± 20.2c | 731.8 ± 55.9b | |
STZ-OFE | 2760.7 ± 323.0a | 1069.9 ± 120.8a | 693.2 ± 96.7ab | 716.7 ± 57.1a | 679.6 ± 65.7b | |
Hippocampus | Control | 288.5 ± 72.8a | 111.7 ± 30.5b | 1041.9 ± 103.6b | 1040.7 ± 71.6a | 257.6 ± 63.9c |
STZ-PBS | 84.6 ± 5.1bc | 129.0 ± 46.9b | 620.2 ± 66.2c | 219.0 ± 5.9b | 423.5 ± 85.8bc | |
STZ-Rosi | 19.9 ± 6.2c | 49.1 ± 28.0bc | 864.3 ± 41.0b | 185.4 ± 63.2b | 702.9 ± 12.1a | |
STZ-OFE | 255.1 ± 56.3a | 317.4 ± 121.3a | 1622.7 ± 83.0a | 280.8 ± 61.5b | 592.2 ± 107.9ab |
DA: dopamine; DOPAC: 3,4-dihydroxy phenlactic acid; 5-HT: 5-hydroxytryptamine; 5-H1AA: 5-hydroxy indole acetic acid. One way ANOVA followed by Tukey’s post hoc test was performed for multiple comparisons. Means in a row with different superscripts, such as a, b, c, ab, bc, is significantly different (p <= 0.05). Values are present as mean ± SEM, n = 6 in control group and n = 8 in the ogher groups