Fig. 2.
Body weight change, food and water intake in euthyroid, T4 or LoI/MMI/ClO4 − treated mice. Time course of the average body weight (BW) of male and female mice over an experimental period of 9 weeks under a control, b T4, and c LoI/MMI/ClO4 − treatment. Average food intake was related to BW during experiment in d euthyroid, e hyperthyroid, and f hypothyroid conditions in mice of both sexes. After run-in period mice were placed on low-iodine diet for the induction of hypothyroidism, or on control iodine diet by the same supplier to adapt the nutritional intake (euthyroid and hyperthyroid groups). Arrows indicate the start of treatment. Time course of average water intake was monitored over the experimental period of 9 weeks under g control, h TH excess, and i TH deprivation of male and female mice. Data are presented as mean ± SD, N = 8 animals/sex/treatment/time point; two-way ANOVA followed by the Bonferroni post hoc analysis applied for time and sex effects, *p < 0.05, **p < 0.01, ***p < 0.001 above graph represent multiple-testing results