Figure 3.

Frequency of alterations in (A) STK11 (encoding LKB1), (B) PRKAA1 (encoding AMPK‐α1) and (C) PRKAA2 (encoding AMPK‐α2) displayed using cBioPortal [66,67] . Data are from a selected group of 43 cancer genome studies, and only those with alterations are displayed. Note how the alterations in STK11 are most frequently mutations (although deletions are particularly prevalent in cervical, ovarian and uterine cancers), whereas PRKAA1 is quite frequently amplified. With some exceptions, alterations in PRKAA2 are mostly mutations, and the frequency is lower (note different scales on the y‐axes).