Fig. 2.

Results of Monte-Carlo analysis of Models 1-4. a Simulation of Models 1-4 with parameter values I=0.87, α=0.11, β=0.17, δ=58.2, n=12.77, K _m=0.23, τ=2.5 without auto-inhibition (κ=0). b,c Stability analysis of Monte-Carlo simulations of Models 1-4. Model parameters were randomly sampled 10000 times in the certain range. The range was defined according to assumptions about model characteristics: strength of DNF (strong or weak) and presence of auto-inhibition. The percentage of parameter sets (see Fig. b), which induced absolute stability, and the mean value of marginal time delay τ _m (see Fig. c) were quantified