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. 2016 Aug 24;13(1):194. doi: 10.1186/s12974-016-0670-z

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — HMGB1 increases BBB permeability to dextrans of various sizes. HCMEC/D3 cells in the transwells were incubated with HMGB1 (5, 10, or 50 ng/ml) for 3 h and the apical to basal flux of a mixture of florescent-labeled dextrans of different sizes (FITC-4 kDa; Cascade Blue 10 kDa; and RITC-70 kDa) was assayed following 30 min after the addition of dextrans. (*p < 0.05 vs. control and N = 5/condition)