Table 3.
Lmx1bb is required for excitatory and not inhibitory neurotransmitter phenotypes
| 27 h | 36 h | 48 h | |||||
|---|---|---|---|---|---|---|---|
| Marker | WT | lmx1bb -/- | WT | lmx1bb -/- | WT | lmx1bb -/- | |
| slc17a6 | Mean | 121.6 | 127.2 | 137.2 | 123.6 | 211 | 175 |
| SEM | 5.3 | 4.1 | 2.5 | 2.4 | 5.5 | 2.9 | |
| n | 10 | 10 | 13 | 17 | 10 | 13 | |
| p value | 0.411 | <0.001 | <0.001 | ||||
| slc32a1 | Mean | 149.7 | 148 | 173.2 | 169.7 | 210.5 | 202 |
| SEM | 2.7 | 5.8 | 10.9 | 17.1 | 4 | 10.8 | |
| n | 10 | 6 | 14 | 7 | 12 | 6 | |
| p value | 0.77 | 0.85 | 0.48 | ||||
Mean number of slc17a6a + slc17a6b (slc17a6) or slc32a1-expressing cells counted in the spinal cord region adjacent to somites 6–10 in 27 h, 36 h and 48 h embryos. SEM is the standard error of the mean. n is the number of embryos analyzed for each data set. p value is from a student’s paired t-test comparing WT and lmx1bb mutant embryos. Statistically significant p values are indicated in bold