Table 5.
lmx1ba and lmx1bb mutant alleles act redundantly in a dose-dependent manner
| 48 h |
lmx1ba
+/+
lmx1bb +/+ |
lmx1ba
+/-
lmx1bb +/+ |
lmx1ba
+/+
lmx1bb +/- |
lmx1ba
+/-
lmx1bb +/- |
lmx1ba
-/-
lmx1bb +/+ |
lmx1ba
+/+
lmx1bb -/- |
lmx1ba
-/-
lmx1bb -/- |
|
|---|---|---|---|---|---|---|---|---|
| slc17a6 | Mean | 246.3 | 250.2 | 233.8 | 196.4 | 199.4 | 204.5 | 193.1 |
| SEM | 7.4 | 5.9 | 4.5 | 5.5 | 10.4 | 10 | 6.2 | |
| n | 8 | 5 | 4 | 8 | 11 | 9 | 13 | |
| p value 1 | n/a | 0.72 | 0.3 | 0.001 | 0.001 | 0.003 | 0.001 | |
| p value 2 | 0.3 | 0.08 | n/a | 0.005 | 0.03 | 0.05 | 0.004 | |
| p value 3 | 0.001 | 0.001 | 0.005 | n/a | 0.66 | 0.38 | 0.78 | |
| p value 4 | 0.003 | 0.004 | 0.05 | 0.38 | 0.7 | n/a | 0.45 | |
| p value 5 | 0.001 | 0.001 | 0.03 | 0.66 | n/a | 0.7 | 0.78 | |
| slc32a1 | Mean | 179.8 | 188.5 | |||||
| SEM | 12.9 | 14.1 | ||||||
| n | 6 | 6 | ||||||
| p value 1 | n/a | 0.94 |
Mean number of slc17a6a + slc17a6b (slc17a6) or slc32a1-expressing cells detected in the spinal cord region adjacent to somites 6–10 in 48 h embryos. SEM is the standard error of the mean. n is the number of embryos analyzed for each data set. p values are from student’s paired t-test. Statistically significant p values are indicated in bold. p value 1 is from comparing WT (lmx1ba +/+ ;lmx1bb +/+) embryos pairwise with all other genotypes, p value 2 is from comparing lmx1ba +/+ ;lmx1bb +/- embryos pairwise with all other genotypes, p value 3 is from comparing lmx1ba +/- ;lmx1bb +/- embryos pairwise with all other genotypes, p value 4 is from comparing lmx1ba +/+ ;lmx1bb -/- embryos pairwise with all other genotypes and p value 5 is from comparing lmx1ba -/- ; lmx1bb +/+ embryos pairwise with all other genotypes