TABLE 2.

Multivariable Cox models for recurrence, for entire population, and those without and with radiation

	Entire population (n=2634)				No-radiation cohort (n=1163)				Radiation cohort (n=1471)
	n	Events	HR	p value	n	Events	HR	p value	n	Events	HR	p value
Age
<40	119	29	1	--	46	15	1	--	59	14	1	--
40 – 49	625	99	0.82	0.36	247	52	0.83	0.54	378	47	0.89	0.71
50 – 59	791	75	0.46	0.0005	305	38	0.45	0.01	486	37	0.52	0.04
60 – 69	641	64	0.50	0.003	263	48	0.69	0.21	378	16	0.32	0.002
70 – 79	362	44	0.56	0.02	220	37	0.64	0.16	142	7	0.37	0.04
≥80	96	5	0.21	0.0015	82	5	0.24	0.006	14	0
Presentation				0.008				0.02				0.25
Clinical	302	59	1		150	38	1		152	21	1
Radiological	2332	257	0.67		1013	157	0.65		1319	100	0.75
Family History				0.02				0.03				0.21
No	1614	180	1		713	109	1		901	71	1
Yes	1020	136	1.31		450	86	1.37		570	50	1.26
Necrosis				0.006				0.004				0.85
Absent	941	105	1		595	79	1		346	26	1
Present	1693	211	1.42		568	116	1.54		1125	95	1.04
Number of excisions				0.01				0.002				0.52
≤2	2433	284	1		1121	179	1		1312	105	1
≥3	201	32	1.64		42	16	2.33		159	16	1.19
Margin status				0.01				0.0004				0.82
Close/positive	522	81	1.39		202	50	1.81		320	31	0.95
Negative	2112	235	1		961	145	1		1151	90	1
Radiation therapy				<0.0001
Yes	1163	195	0.42				NA				NA
No	1471	121	1
Endocrine therapy				<0.0001				0.006				0.001
Yes	587	39	0.50		189	20	0.52		398	19	0.44
No	2047	277	1		974	175	1		1073	102	1
Year of surgery				0.005				0.001				0.91
≤1998	567	145	1		331	100	1		236	45	1
≥1999	2067	171	0.7		832	95	0.61		1235	76	0.98