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. 2016 Aug 19;84(9):2595–2606. doi: 10.1128/IAI.00329-16

TABLE 1.

Deleted regions in N. brasiliensis P-200a

Region no. Deleted region
Gene Protein Corresponding region in reference sequence
Organism(s) with ortholog NCBI COG
Start position End position Start position End position
1 541011 541445 03I_002340 Clp protease 540929 543247 Nocardia cyriacigeorgica, Nocardia farcinica, Rhodococcus jostii COG0542
2 1449785 1450050 Intergenic region
3 1453274 1453310 Intergenic region
4 1501900 1533608 03I_006545 Putative drug resistance transporter 1500162 1502150 N. cyriacigeorgica, N. farcinica COG0477
03I_006550 PadR family transcriptional regulator 1502234 1502887 N. cyriacigeorgica, N. farcinica COG1695
03I_006555 Monooxygenase, FAD-binding protein 1503068 1504273 N. cyriacigeorgica, N. farcinica COG0654
03I_006560 ATP-binding transport protein NatA 1504341 1505108 N. brasiliensis COG1131
03I_006565 Hypothetical protein 1505093 1506658 N. brasiliensis
03I_006570 LysR family transcriptional regulator 1506719 1507639 N. brasiliensis COG0583
03I_006575 XRE family transcriptional regulator 1507644 1508447 N. cyriacigeorgica, R. jostii COG1396
03I_006580 Hypothetical protein 1508578 1509024 N. cyriacigeorgica
03I_006585 Hypothetical protein 1509060 1509791 N. cyriacigeorgica, R. jostii
03I_006590 Haloalkane dehalogenase 1510380 1511252 N. cyriacigeorgica COG0596
03I_006595 Putative RNA polymerase ECF-type sigma factor 1511337 1512200 N. cyriacigeorgica COG1595
03I_006600 C4-dicarboxylate transporter/malic acid transport protein 1512157 1513347 N. cyriacigeorgica, R. jostii COG1275
03I_006605 LysR family transcriptional regulator 1513418 1514326 N. cyriacigeorgica, R. jostii COG0583
03I_006610 Phosphate uptake regulator PhoU 1514345 1515028 N. cyriacigeorgica, N. farcinica COG0704
03I_006615 Transglutaminase domain-containing protein 1515153 1515956 R. jostii COG1305
03I_006620 Na-Ca exchanger/integrin-beta4 1515963 1516991 N. brasiliensis
03I_006625 Pyridoxamine 5′-phosphate oxidase-related FMN-binding protein 1518688 1519095 N. cyriacigeorgica COG3467
03I_006630 Transporter 1519200 1520300 N. farcinica, R. jostii COG0387
03I_006635 YrbE family protein 1520752 1520752 N. cyriacigeorgica, N. farcinica COG0767
03I_006640 YrbE family protein 1521601 1522467 N. cyriacigeorgica, N. farcinica COG0767
03I_006645 Mce family protein 1522498 1522498 N. cyriacigeorgica, N. farcinica COG3008
03I_006650 Mce family protein 1523496 1524497 N. cyriacigeorgica, N. farcinica COG1463
03I_006655 Mce family protein 1524485 1525519 N. cyriacigeorgica, N. farcinica COG1463
03I_006660 Mce family protein 1525489 1526604 N. cyriacigeorgica, N. farcinica COG1463
03I_006665 Mce family protein 1526601 1526601 N. cyriacigeorgica, N. farcinica COG0282
03I_006670 Mce family protein 1527728 1527728 N. cyriacigeorgica, N. farcinica COG1463
03I_006675 Hypothetical protein 1528699 1529298 N. cyriacigeorgica, N. farcinica
03I_006680 Hypothetical protein 1529433 1529433 N. brasiliensis
03I_006685 Aminoglycoside O-phosphotransferase 1530067 1530951 N. cyriacigeorgica, N. farcinica, R. jostii COG3570
03I_006690 Short-chain dehydrogenase/reductase SDR 1530978 1530978 N. brasiliensis COG1028
03I_006695 Signal transduction histidine kinase 1532065 1533246 N. brasiliensis COG4585
03I_006700 Two-component LuxR family transcriptional regulator 1533243 1533890 N. brasiliensis COG2197
5 2271950 2277016 03I_Or42277 16S rRNA 2271959 2273488
6 2372465 2372842 03I_010455 Glyoxylate carboligase 2372219 2373994 COG3960
7 2578134 2578295 Intergenic region
8 2933006 2933045 Intergenic region
9 3597423 3597782 03I_016110 DNA-directed RNA polymerase subunit beta (RpoB) 3596307 3599822 N. cyriacigeorgica, N. farcinica, R. jostii
10 3901876 3903739 03I_Or42279 16S rRNA 3902217 3903746
11 3904013 3907228 Intergenic region
12 4429801 4429809 Intergenic region
13 4795932 5012300 03I_021225 Gamma-glutamyltransferase 4795342 4797141 N. brasiliensis COG0405
03I_021230 Methyltransferase 4797178 4798242 N. brasiliensis COG0500
03I_021235 Cytochrome P-450 4798239 4799441 R. jostii COG2124
03I_021240 Alcohol dehydrogenase GroES domain-containing protein 4799438 4800493 N. brasiliensis COG1064
03I_021245 Aldehyde dehydrogenase 4800513 4802000 N. farcinica, R. jostii COG1012
03I_021250 Putative amidotransferase 4802029 4803891 R. jostii COG0367
03I_021255 ABC transporter 4803936 4806227 N. cyriacigeorgica, N. farcinica, R. jostii COG0178
03I_021260 Short-chain fatty acid MFS superfamily protein 4806415 4807854 R. jostii COG2031
03I_021265 Hypothetical protein 4807919 4808521 N. brasiliensis
03I_021270 Hypothetical protein 4808582 4809127 N. farcinica
03I_021275 Hypothetical protein 4809244 4810527 N. brasiliensis
03I_021280 Hypothetical protein 4810655 4811164 N. farcinica COG2259
03I_021285 Hypothetical protein 4811244 4812002 N. farcinica, R. jostii COG3384
03I_021290 MarR family transcriptional regulator 4812093 4812554 N. farcinica, R. jostii COG1846
03I_021295 NADP-dependent oxidoreductase domain-containing protein 4812632 4813675 R. jostii COG0667
03I_021300 Abortive infection protein 4813887 4814675 N. brasiliensis COG1266
03I_021305 Dioxygenase 4814780 4815688 N. farcinica COG2175
03I_021310 Transporter 4815883 4816527 N. farcinica COG1174
03I_021315 ABC transporter ATP-binding protein 4816524 4817804 N. farcinica COG1125
03I_021320 ABC transporter permease 4817801 4818538 N. farcinica COG1174
03I_021325 Transporter permease 4818535 4819515 N. farcinica COG1732
03I_021330 Hypothetical protein 4819550 4820365 N. farcinica, R. jostii
03I_021335 Hypothetical protein 4820488 4821048 N. brasiliensis
03I_021340 Nonribosomal peptide synthetase 4821049 4841793 N. cyriacigeorgica, N. farcinica, R. jostii COG1020
03I_021345 Hypothetical protein 4841793 4857035 N. cyriacigeorgica, N. farcinica, R. jostii COG1020
03I_021350 SARP family transcriptional regulator 4857537 4860785 N. brasiliensis COG0745
03I_021355 Hypothetical protein 4860727 4861287 N. brasiliensis
03I_021360 Hypothetical protein 4861313 4862404 N. brasiliensis COG0451
03I_021365 Nonribosomal peptide synthetase 4862392 4863786 N. brasiliensis COG1020
03I_021370 Acetylornithine deacetylase or succinyl-diaminopimelate desuccinylase 4863783 4864988 R. jostii COG0624
03I_021375 UbiE/COQ5 family methyltransferase 4865045 4865869 N. brasiliensis COG0500
03I_021380 Alcohol dehydrogenase 4866058 4867254 N. farcinica, R. jostii COG1454
03I_021385 Sensor histidine kinase 4867244 4868566 N. brasiliensis
03I_021390 d-3-Phosphoglycerate dehydrogenase 4868598 4869608 R. jostii COG0111
03I_021395 Phosphoenolpyruvate phosphomutase 4869662 4870588 N. brasiliensis COG2513
03I_021400 Phosphonopyruvate decarboxylase 4870585 4871736 N. brasiliensis COG4032
03I_021405 Aldehyde dehydrogenase 4871726 4873117 N. brasiliensis COG1012
03I_021410 Short-chain dehydrogenase/reductase SDR 4873151 4873954 N. brasiliensis COG1028
03I_021415 Polyketide synthase 4873956 4874171 N. brasiliensis COG3321
03I_021420 AMP-dependent synthetase and ligase 4874171 4875613 N. brasiliensis COG0318
03I_021425 Class III aminotransferase 4875616 4876941 N. brasiliensis COG0160
03I_021430 Hypothetical protein 4876976 4877728 N. brasiliensis COG0842
03I_021435 ABC transporter-like protein 4877725 4878678 N. brasiliensis COG1131
03I_021440 Penicillin-binding protein 4878669 4879817 N. brasiliensis, R. jostii COG1680
03I_021445 Pantoate–beta-alanine ligase PanC 4879877 4880716 N. brasiliensis COG0414
03I_021450 LuxR family transcriptional regulator 4880906 4881586 N. brasiliensis COG2197
03I_021455 Integral membrane sensor signal transduction histidine kinase 4881576 4882817 N. brasiliensis COG4585
03I_021460 Hypothetical protein 4882983 4883552 N. brasiliensis
03I_021465 Hypothetical protein 4883543 4883869 N. brasiliensis
03I_021470 Hypothetical protein 4883931 4884668 N. brasiliensis, N. farcinica, R. jostii COG3393
03I_021475 LuxR family transcriptional regulator 4884766 4887378 N. brasiliensis, R. jostii COG1066
03I_021480 Hypothetical protein 4887544 4887990 N. brasiliensis, R. jostii
03I_021485 Hypothetical protein 4888075 4888605 N. brasiliensis
03I_021490 Hypothetical protein 4888830 4889687 N. brasiliensis, N. farcinica COG0693
03I_021495 HTH-type transcriptional regulator GlxA 4889733 4890743 N. brasiliensis, N. cyriacigeorgica COG4977
03I_021500 Exonuclease SbcC 4890883 4891464 N. brasiliensis, N. farcinica, R. jostii
03I_021505 Helix-turn-helix domain-containing protein 4891566 4892396 N. brasiliensis, N. cyriacigeorgica COG2207
03I_021510 Hypothetical protein 4892421 4892924 N. brasiliensis, N. cyriacigeorgica
03I_021515 Hypothetical protein 4893061 4893711 N. brasiliensis
03I_021520 Putative transcriptional regulator TetR 4893718 4894305 N. brasiliensis, N. farcinica COG1309
03I_021525 Phytanoyl-coenzyme A (CoA) dioxygenase (PhyH) family protein 4894403 4895257 N. brasiliensis, N. farcinica, R. jostii COG5285
03I_021530 Hypothetical protein 4895383 4896189 N. brasiliensis
03I_021535 Peptidase M14 carboxypeptidase 4896301 4897695 N. brasiliensis COG2866
03I_021540 Glutamate-cysteine ligase GCS2 4897981 4899078 N. brasiliensis COG2170
03I_021545 Hypothetical protein 4899169 4899396 N. brasiliensis
03I_021550 Short-chain dehydrogenase 4899479 4900318 N. brasiliensis, N. cyriacigeorgica, N. farcinica, R. jostii COG1028
03I_021555 FAD-binding monooxygenase 4900447 4902174 N. brasiliensis
03I_021560 Luciferase 4902171 4903256 N. brasiliensis COG2141
03I_021565 Pyridoxal-5′-phosphate-dependent protein subunit beta 4903272 4904462 N. brasiliensis COG0498
03I_021570 Opine dehydrogenase 4904459 4905574 N. brasiliensis, N. farcinica
03I_021575 Acyl-CoA reductase 4905577 4907022 N. brasiliensis
03I_021580 Hypothetical protein 4907010 4908308 N. brasiliensis
03I_021585 Ferredoxin 4908610 4908825 N. brasiliensis COG1141
03I_021590 LuxE bioluminescence protein 4908850 4909983 N. brasiliensis COG1541
03I_021595 Acyltransferase LuxD 4910022 4910987 N. brasiliensis
03I_021600 Sodium/hydrogen exchanger 4910945 4912375 N. brasiliensis COG0475
03I_021605 Fluorinating enzyme 4912446 4913309 N. brasiliensis COG1912
03I_021610 S-Adenosyl-l-homocysteine hydrolase 4913437 4914891 N. brasiliensis, N. cyriacigeorgica, N. farcinica, R. jostii COG0499
03I_021615 Methylthioadenosine phosphorylase 4915122 4916000 N. brasiliensis COG0005
03I_021620 Adenine phosphoribosyltransferase 4916036 4916611 N. brasiliensis COG0503
03I_021625 Translation initiation factor, aIF-2BI family protein 4916581 4917585 N. brasiliensis COG0182
03I_021630 Serine hydroxymethyltransferase GlyA 4917783 4919630 N. brasiliensis, R. jostii COG0112
03I_021635 DNA-binding regulatory protein 4919638 4920213 N. brasiliensis COG1396
03I_021640 Hypothetical protein 4920272 4921222 N. brasiliensis COG0697
03I_021645 Two-component system response regulator 4921827 4922435 N. brasiliensis COG2197
03I_021650 Universal stress protein UspA-like protein 4922436 4922879 N. brasiliensis COG0589
03I_021655 Hypothetical protein 4922918 4923145 N. brasiliensis
03I_021660 Hypothetical protein 4923186 4923701 N. brasiliensis COG2606
03I_021665 OsmC-like protein 4923894 4924364 N. brasiliensis, R. jostii COG1764
03I_021670 Peptidase M15A 4924375 4926096 N. brasiliensis COG3108
03I_021675 Peptidase M15A 4926115 4928226 N. brasiliensis
03I_021680 Hypothetical protein 4928280 4929614 N. brasiliensis
03I_021685 Hypothetical protein 4929628 4930167 N. brasiliensis
03I_021690 Hypothetical protein 4930190 4931440 N. brasiliensis
03I_021695 Hypothetical protein 4931440 4933926 N. brasiliensis
03I_021700 Hypothetical protein 4933923 4934150 N. brasiliensis
03I_021705 SARP family transcriptional regulator 4934354 4935067 N. brasiliensis COG3629
03I_021710 Hypothetical protein 4934996 4936714 N. brasiliensis
03I_021715 SARP family transcriptional regulator 4936750 4937550 N. brasiliensis COG3629
03I_021720 Alpha/beta-fold hydrolase 4937701 4938486 N. brasiliensis COG0596
03I_021725 Oxidoreductase 4938581 4939534 N. brasiliensis COG0604
03I_021730 TetR family transcriptional regulator 4939638 4940246 N. brasiliensis COG1309
03I_021735 FAD-linked oxidase domain-containing protein 4940308 4941654 N. brasiliensis COG0277
03I_021740 Hypothetical protein 4941757 4942299 N. brasiliensis, N. cyriacigeorgica, R. jostii COG5485
03I_021745 4-Carboxymuconolactone decarboxylase 4942296 4942679 N. brasiliensis COG0599
03I_021750 3-Oxoadipate enol-lactonase 4942676 4943452 N. brasiliensis, R. jostii COG0596
03I_021755 3-Carboxy-cis,cis-muconate cycloisomerase 4943449 4944795 N. brasiliensis, R. jostii COG0015
03I_021760 Protocatechuate 3,4-dioxygenase alpha subunit 4944788 4945312 N. brasiliensis, R. jostii COG3485
03I_021765 Protocatechuate 3,4-dioxygenase beta subunit 4945305 4946045 N. brasiliensis, R. jostii COG3485
03I_021780 CoA transferase B subunit 4947234 4948013 N. brasiliensis, N. farcinica, R. jostii COG2057
03I_021785 CoA transferase A subunit 4948010 4948825 N. brasiliensis, N. farcinica, R. jostii COG1788
03I_021790 4-Hydroxybenzoate 3-monooxygenase 4948828 4950030 N. brasiliensis, R. jostii COG0654
03I_021795 Transmembrane transport protein 4950027 4951259 N. brasiliensis, R. jostii COG0477
03I_021800 LysR family transcriptional regulator 4951362 4952264 N. brasiliensis, R. jostii COG0583
03I_021805 Glycosidase 4952276 4954621 N. brasiliensis, R. jostii COG1554
03I_021810 Hydrolase 4954618 4955349 N. brasiliensis, R. jostii COG0637
03I_021825 Hypothetical protein 4956335 4957054 N. brasiliensis, N. cyriacigeorgica, N. farcinica COG2129
03I_021830 DsbA oxidoreductase 4957051 4957644 N. brasiliensis
03I_021835 Transcriptional regulator 4957793 4958872 N. brasiliensis COG2207
03I_021840 Cell surface protein 4959086 4959961 N. brasiliensis
03I_021845 Hypothetical protein 4960040 4960426 N. brasiliensis
03I_021850 Putative cysteine synthase 4960527 4961639 N. brasiliensis, N. cyriacigeorgica, N. farcinica COG0031
03I_021855 Putative MFS transporter 4961636 4962907 N. brasiliensis, N. cyriacigeorgica, N. farcinica COG0477
03I_021860 Amino acid binding protein 4962998 4964092 N. brasiliensis, R. jostii
03I_021865 Sigma factor 4964772 4965512 N. brasiliensis COG1191
03I_021870 Hypothetical protein 4965603 4965887 N. brasiliensis
03I_021875 AraC family transcriptional regulator 4965976 4966569 N. brasiliensis COG2207
03I_021880 Hypothetical protein 4966735 4966926 N. brasiliensis
03I_021885 5,10-Methylenetetrahydrofolate reductase 4967383 4968366 N. brasiliensis, N. cyriacigeorgica, N. farcinica, R. jostii COG0685
03I_021890 Hypothetical protein 4968457 4968840 N. brasiliensis, N. farcinica, R. jostii
03I_021895 Glyoxalase/bleomycin resistance protein/dioxygenase 4968853 4969248 N. brasiliensis COG0346
03I_021900 Thimet oligopeptidase 4969268 4971199 N. brasiliensis COG0339
03I_021905 PadR-like family transcriptional regulator 4971239 4971832 N. brasiliensis COG1695
03I_021910 Ferredoxin 4971845 4973587 N. brasiliensis, R. jostii COG1018
03I_021915 Hypothetical protein 4973826 4974689 N. brasiliensis, N. cyriacigeorgica, N. farcinica COG0596
03I_021920 Hypothetical protein 4974798 4975796 N. brasiliensis, N. cyriacigeorgica, N. farcinica, R. jostii
03I_021925 Methyltransferase 4975793 4976491 N. brasiliensis, N. cyriacigeorgica, N. farcinica, R. jostii COG2890
03I_021930 Hypothetical protein 4976529 4976678 N. brasiliensis, N. cyriacigeorgica, N. farcinica COG3369
03I_021935 Oxidoreductase 4976757 4978205 N. brasiliensis, N. cyriacigeorgica COG0665
03I_021940 Hypothetical protein 4978223 4978432 N. brasiliensis
03I_021945 Catalase 4978659 4980830 N. brasiliensis, N. cyriacigeorgica, N. farcinica, R. jostii COG0753
03I_021950 Cytochrome P450 monooxygenase 4980837 4982192 N. brasiliensis COG2124
03I_021955 DNA ligase 4982302 4984293 N. brasiliensis, N. farcinica COG0272
03I_021960 Propionyl-CoA carboxylase beta chain (PCCase) (propanoyl-CoA:carbon dioxide ligase) 4984482 4986032 N. brasiliensis, N. cyriacigeorgica, N. farcinica, R. jostii COG4799
03I_021965 Hypothetical protein 4986188 4986607 N. brasiliensis
03I_021970 Hypothetical protein 4986612 4987046 N. brasiliensis
03I_021975 Serine/threonine protein kinase 4987060 4988448 N. brasiliensis COG0515
03I_021980 Hypothetical protein 4988845 4990197 N. brasiliensis, R. jostii
03I_021985 Type 11 methyltransferase 4990248 4991027 N. brasiliensis COG0500
03I_021990 Hypothetical protein 4991125 4991433 N. brasiliensis
03I_021995 Hypothetical protein 4991467 4993941 N. brasiliensis, R. jostii
03I_022000 DNA-binding protein 4994209 4995144 N. brasiliensis COG1396
03I_022005 Monooxygenase FAD-binding protein 4995520 4997040 N. brasiliensis COG0654
03I_022010 Hypothetical protein 4997078 4997308 N. brasiliensis
03I_022015 LysR family transcriptional regulator 4997443 4998345 N. brasiliensis COG0583
03I_022020 Cobalt ABC transporter ATPase 4998379 4999098 N. brasiliensis, R. jostii COG1122
03I_022025 ABC transporter permease 4999095 4999856 N. brasiliensis, R. jostii COG0619
03I_022030 Cobalamin (vitamin B12) biosynthesis CbiM protein 4999857 5000921 N. brasiliensis, R. jostii COG0310
03I_022035 ArsR family transcriptional regulator 5001072 5001416 N. brasiliensis COG0640
03I_022040 Hypothetical protein 5001435 5002505 N. brasiliensis COG3236
03I_022045 Cupin 5002682 5003389 N. brasiliensis, R. jostii COG2140
03I_022050 RNA polymerase factor sigma 70 5003373 5004428 N. brasiliensis COG1595
03I_022055 NADPH:quinone reductase and related Zn-dependent oxidoreductase 5004425 5005423 N. brasiliensis COG0604
03I_022060 Hypothetical protein 5005604 5006257 N. brasiliensis, N. cyriacigeorgica, N. farcinica
03I_022065 Putative AraC family transcriptional regulator 5006364 5007230 N. brasiliensis, N. cyriacigeorgica COG2207
03I_022070 Hydrolase 5007230 5008423 N. brasiliensis COG1680
03I_022075 Hypothetical protein 5008639 5009004 N. brasiliensis COG0346
03I_022080 Hypothetical protein 5009015 5009701 N. brasiliensis COG5479
03I_022085 MarR family transcriptional regulator 5009886 5010323 N. brasiliensis, N. cyriacigeorgica, R. jostii COG1846
03I_022090 Hypothetical protein 5010400 5011047 N. brasiliensis, N. cyriacigeorgica
03I_022095 Hypothetical protein 5011268 5011873 N. brasiliensis
03I_022100 Putative membrane porin 5011922 5012581 N. brasiliensis COG0094
14 5025398 5027080 03I_022175 Nitrate reductase Z subunit beta (NarY) 5024840 5026579 N. cyriacigeorgica, N. farcinica COG1140
15 5029253 5029670 03I_022190 Nitrate reductase Z subunit alpha (NarZ) 5029170 5030117 COG5013
16 5393100 5393780 03I_023565 Putative peptidase 5392840 5393805 N. brasiliensis COG3590
17 5867835 5868021 Intergenic region
a

The data were prepared by aligning the contigs obtained for P-200 with the reference sequence (accession number NC_18681.1) by using Sequencer software. The orthologous genes were determined by using BLAST searches.