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Bone destruction and reactive bone formation in osteomyelitis as a function of sarA. C57BL/6 mice (n = 5) were infected with LAC, UAMS-1 (U1), or their isogenic sarA mutants (ΔsarA). Femurs were harvested at 14 days after inoculation and subjected to micro-CT imaging analysis. Anteroposterior views of infected femurs are shown for comparison. Sham, results for mice subjected to the surgical procedure and injected with sterile PBS.
