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Model depicting assembly of VacA monomers into hexameric structures. The density map of VacA-Δ(346-347)-Str312 was fitted into an EM map of a VacA hexamer (31). The figure illustrates bottom, top, and side views of the hexamer. Blue indicates p55 domains, and red indicates an ∼165-amino-acid β-helical segment within the p33 domain.
