FIG 1.
Effect of CPAF deficiency on chlamydial survival/infectivity in the lower genital tracts of mice following an intravaginal inoculation. Seven-week-old C3H/HeJ female mice were each inoculated with 5 × 106 inclusion-forming units (IFUs) of L2-17 (panel a, n = 15), L2-5 (panel b, n = 8), or L2wt (panel c, n = 15) intravaginally. On different days after inoculation as indicated along the x axis, vaginal swabs were taken for monitoring recovery of live chlamydial organism. The recovered live organisms were expressed as log10 IFUs per swab and presented individually (open circles) along the y axis. Each horizontal bar represents the median for each group. The data came from 3 independent experiments. Note that mice intravaginally inoculated with L2-17 displayed a significantly lower level of live-organism recovery than the mice similarly infected with L2-5 or L2wt (Wilcoxon; **, P < 0.01).