Fig. 4.

Characterization of seizure-like activities and SD in vitro. Representative traces from WT (A) and RQ mutant cortical slices (B) exposed to Mg²⁺-free ACSF solution. High pass-filtered recording (Top) and DC components (Bottom) from the same recordings are presented. Arrowheads indicate spontaneous seizure-like activity (Top) and SD (Bottom). The number of SD events was greater in RQ mutant than +/+ slices (C), whereas the numbers (D) and durations (E) of seizure events were not different. For each genotype, 10 slices from 3 mice were used. Bar graph, mean ± standard deviation.