Table S3.

Oligonucleotides were used for synthesis of sgRNA template

Primer name	Sequence
CRISPR forward primer for miR-309 sgRNA	GAAATTAATACGACTCACTATAGGAAGGTTTCCAGTTTCATCACGTTTTAGAGCTAGAAATAGC
CRISPR forward primer for KMO sgRNA	GAAATTAATACGACTCACTATAGGCACAGTACAATCCTCGAATCGTTTTAGAGCTAGAAATAGC
CRISPR Universal reverse primer*	AAAAGCACCGACTCGGTGCCACTTTTTCAAGTTGATAACGGACTAGCCTTATTTTAACTTGCTATTTCTAGCTCTAAAAC

^*Each specific forward primer can generate one specific sgRNA when overlapped with universal reverse primer.