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Interactions of EFdA-MP•dA-MP mismatch. Hoogsteen base pairing between EFdA-MP and dA-MP in the RT/DNAEFdA-MPP•EFdA-MP*N structure, superposed on a hypothetical non-Hoogsteen base pairing. Green/red Fo-Fc maps (σ = ±2.4) indicate that the mismatched adenine (light gray) should be flipped and modeled as Hoogsteen base paired as it better fits the crystallographic data.
