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Domain dissection of Hsp90β reveals a druggable site in the MD. Various 3×F-Hsp90β truncation mutants were made and transfected into HEK293 cells. STA-7346 was used as a representative NTD-targeted inhibitor and bound to all fragments that included the NTD. Bio-GBA was only able to bind to Hsp90β fragments that contained at least the first 432 residues. In contrast to STA-7346, GBA binding did not require the NTD. See Fig. S2 for the raw data supporting this figure.
