Fig. 2.

Cytokine involvement in adiposity signalling. The adiposity signalling pathway of inflammatory cytokines is shown. Cytokines, which are elevated during fat accumulation, act within the hypothalamus to initiate anorexigenic pathways, to ultimately decrease food intake and increase energy expenditure. Once caloric restriction is achieved, cytokine levels are reduced. Antipsychotics may perturb adiposity signalling by reducing central cytokine levels, thereby blocking the illustrated pathway at the level of the hypothalamus, and shifting weight outcomes back toward fat accumulation.