Table 5.
Demographic and symptom data by psychiatric diagnosis
| BP |
Schizophrenia |
Normal control |
Statistics | ||||
|---|---|---|---|---|---|---|---|
| n | mean ± SD | n | mean ± SD | n | mean ± SD | ||
| Subjects, n | 9 | 8 | 12 | ||||
| Family psychiatric history (yes/no) | 3/41 | 4/32 | 0/122 | p = 0.014 | |||
| Handedness (left/right) | 1/61 | 3/5 | 0/12 | p = 0.2 | |||
| Ethnicity (Hispanic/Anglo-American) | 2/7 | 3/5 | 2/10 | p = 0.6 | |||
| Sex (male/female) | 6/3 | 6/2 | 9/3 | p = 0.9 | |||
| Smoking (yes/no) | 5/4 | 8/0 | 8/4 | p = 0.1 | |||
| Suicide (yes/no) | 5/4 | 1/7 | 0/12 | p = 0.06 | |||
| Substance use disorder (yes/no) | 1/8 | 1/7 | 0/12 | p = 0.9 | |||
| AUD (yes/no) | 5/4 | 2/6 | 0/12 | p = 0.2 | |||
| Antidepressant use (yes/no) | 5/4 | 3/5 | 0/12 | p = 0.8 | |||
| Benzodiazepine use (yes/no) | 1/8 | 1/7 | 0/12 | p = 0.9 | |||
| Antiseizure mood stabilizer use (yes/no) | 3/6 | 1/7 | 0/12 | p = 0.3 | |||
| Neuroleptic use (yes/no) | 3/6 | 4/4 | 0/12 | p = 0.5 | |||
| Age, years | 47 ± 6.2 | 50 ± 11 | 56 ± 16 | F(2, 26) = 1.6, p = 0.2 | |||
| Postmortem interval, h | 27 ± 6.7 | 30 ± 4.6 | 26 ± 4.7 | F(2, 26) = 1.6, p = 0.2 | |||
| pH | 6.4 ± 0.3 | 6.3 ± 0.3 | 6.3 ± 0.3 | F(2, 26) = 0.76, p = 0.5 | |||
| RNA integrity number | 7 ± 0.8 | 6.2 ± 1.2 | 7.4 ± 0.78 | F(2, 26) = 3.8, p = 0.045 | |||
| Total BISS score | 38 ± 291 | 35 ± 251 | 3 ± 3.43 | p = 0.0014 | |||
| BISS mania factor score | 8 ± 11 | 17 ± 13 | 1 ± 2 | p = 0.0094 | |||
| BISS depression factor score | 18 ± 14 | 11 ± 10 | 2 ± 2 | p = 0.0084 | |||
| BISS irritability factor score | 5 ± 5 | 7 ± 6 | 0 ± 0 | p = 0.0014 | |||
| BISS anxiety factor score | 6 ± 6 | 3 ± 4 | 0.2 ± 1 | p = 0.0034 | |||
| BISS psychosis factor score | 6 ± 6 | 3 ± 4 | 0 ± 0 | p = 0.0144 | |||
| BPRS | 31 ± 14 | 41 ± 15 | 16 ± 6 | p = 0.0014 | |||
| Barratt Impulsiveness score | 78 ± 18 | 86 ± 16 | 46 ± 9 | p = 0.0014 | |||
BPRS = Brief Psychiatric Rating Scale. Bold print indicates p < 0.05.
1
Data not available for 2 subjects.
2
Data not available for 1 subject.
3
Data not available for 3 subjects.
4
Significant (p < 0.05) difference between normal control and BP, and between normal control and schizophrenia groups.
5
Significant difference (p < 0.05) between normal control and schizophrenia groups.