Impaired PPI in Nrg3 KO mice (y-axis: % of PPI, x-axis: different intensities of prepulse in dB). Two-way repeated measures ANOVA detected a significant effect of genotype [F(1,169) = 5.5, p = 0.02] and intensity of prepulse [F(4,169) = 21.51, p < 0.001], but no interaction between these factors. KO: n = 16, WT: n = 17.