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. 1986 Jan;39(1):8–15. doi: 10.1136/jcp.39.1.8

Immunophenotype analysis of malignant histiocytosis of the intestine.

D M Salter, A S Krajewski, A E Dewar
PMCID: PMC499606  PMID: 3512610

Abstract

Five cases of malignant histiocytosis of the intestine and one case of true histiocytic lymphoma were studied using immunohistological techniques. In paraffin sections tumour cells in all cases were shown to contain alpha-1-antitrypsin and to express the leucocyte common antigen. Four of the five cases of malignant histiocytosis of the intestine and the case of histiocytic lymphoma expressed the epithelial membrane antigen. Cryostat sections in four cases of malignant histiocytosis of the intestine showed that most tumour cells reacted with anti-T cell monoclonal antibodies. Only a minority expressed a typical monocyte macrophage phenotype.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Abo T., Balch C. M. A differentiation antigen of human NK and K cells identified by a monoclonal antibody (HNK-1). J Immunol. 1981 Sep;127(3):1024–1029. [PubMed] [Google Scholar]
  2. Breard J., Reinherz E. L., Kung P. C., Goldstein G., Schlossman S. F. A monoclonal antibody reactive with human peripheral blood monocytes. J Immunol. 1980 Apr;124(4):1943–1948. [PubMed] [Google Scholar]
  3. Brodsky F. M. A matrix approach to human class II histocompatibility antigens: reactions of four monoclonal antibodies with the products of nine haplotypes. Immunogenetics. 1984;19(3):179–194. doi: 10.1007/BF00364762. [DOI] [PubMed] [Google Scholar]
  4. Brooks D. A., Bradley J., Zola H. A differentiation antigen expressed selectively by a proportion of human blood cells: detection with a monoclonal antibody. Pathology. 1982 Jan;14(1):5–11. doi: 10.3109/00313028209069036. [DOI] [PubMed] [Google Scholar]
  5. Brooks D. A., Zola H., McNamara P. J., Bradley J., Bradstock K. F., Hancock W. W., Atkins R. C. Membrane antigens of human cells of the monocyte/macrophage lineage studied with monoclonal antibodies. Pathology. 1983 Jan;15(1):45–52. doi: 10.3109/00313028309061401. [DOI] [PubMed] [Google Scholar]
  6. Daffos F., Forestier F., Grangeot-Keros L., Capella Pavlovsky M., Lebon P., Chartier M., Pillot J. Prenatal diagnosis of congenital rubella. Lancet. 1984 Jul 7;2(8393):1–3. doi: 10.1016/s0140-6736(84)91993-7. [DOI] [PubMed] [Google Scholar]
  7. Dalchau R., Kirkley J., Fabre J. W. Monoclonal antibody to a human leukocyte-specific membrane glycoprotein probably homologous to the leukocyte-common (L-C) antigen of the rat. Eur J Immunol. 1980 Oct;10(10):737–744. doi: 10.1002/eji.1830101003. [DOI] [PubMed] [Google Scholar]
  8. Gerdes J., Naiem M., Mason D. Y., Stein H. Human complement (C3b) receptors defined by a mouse monoclonal antibody. Immunology. 1982 Apr;45(4):645–653. [PMC free article] [PubMed] [Google Scholar]
  9. Guy K., Van Heyningen V., Cohen B. B., Deane D. L., Steel C. M. Differential expression and serologically distinct subpopulations of human Ia antigens detected with monoclonal antibodies to Ia alpha and beta chains. Eur J Immunol. 1982 Nov;12(11):942–948. doi: 10.1002/eji.1830121109. [DOI] [PubMed] [Google Scholar]
  10. Hanjan S. N., Kearney J. F., Cooper M. D. A monoclonal antibody (MMA) that identifies a differentiation antigen on human myelomonocytic cells. Clin Immunol Immunopathol. 1982 May;23(2):172–188. doi: 10.1016/0090-1229(82)90106-4. [DOI] [PubMed] [Google Scholar]
  11. Heyderman E., Steele K., Ormerod M. G. A new antigen on the epithelial membrane: its immunoperoxidase localisation in normal and neoplastic tissue. J Clin Pathol. 1979 Jan;32(1):35–39. doi: 10.1136/jcp.32.1.35. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Hsu S. M., Jaffe E. S. Leu M1 and peanut agglutinin stain the neoplastic cells of Hodgkin's disease. Am J Clin Pathol. 1984 Jul;82(1):29–32. doi: 10.1093/ajcp/82.1.29. [DOI] [PubMed] [Google Scholar]
  13. Isaacson P. G., Jones D. B. Immunohistochemical differentiation between histiocytic and lymphoid neoplasms. Histochem J. 1983 Jul;15(7):621–635. doi: 10.1007/BF01002984. [DOI] [PubMed] [Google Scholar]
  14. Isaacson P. G., O'Connor N. T., Spencer J., Bevan D. H., Connolly C. E., Kirkham N., Pollock D. J., Wainscoat J. S., Stein H., Mason D. Y. Malignant histiocytosis of the intestine: a T-cell lymphoma. Lancet. 1985 Sep 28;2(8457):688–691. doi: 10.1016/s0140-6736(85)92930-7. [DOI] [PubMed] [Google Scholar]
  15. Isaacson P., Jones D. B., Sworn M. J., Wright D. H. Malignant histiocytosis of the intestine: report of three cases with immunological and cytochemical analysis. J Clin Pathol. 1982 May;35(5):510–516. doi: 10.1136/jcp.35.5.510. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Isaacson P., Wright D. H. Intestinal lymphoma associated with malabsorption. Lancet. 1978 Jan 14;1(8055):67–70. doi: 10.1016/s0140-6736(78)90004-1. [DOI] [PubMed] [Google Scholar]
  17. Isaacson P., Wright D. H. Malignant histiocytosis of the intestine. Its relationship to malabsorption and ulcerative jejunitis. Hum Pathol. 1978 Nov;9(6):661–677. doi: 10.1016/s0046-8177(78)80049-5. [DOI] [PubMed] [Google Scholar]
  18. Murphy G. F., Bhan A. K., Sato S., Mihm M. C., Jr, Harrist T. J. A new immunologic marker for human Langerhans cells. N Engl J Med. 1981 Mar 26;304(13):791–792. doi: 10.1056/NEJM198103263041320. [DOI] [PubMed] [Google Scholar]
  19. Naiem M., Gerdes J., Abdulaziz Z., Stein H., Mason D. Y. Production of a monoclonal antibody reactive with human dendritic reticulum cells and its use in the immunohistological analysis of lymphoid tissue. J Clin Pathol. 1983 Feb;36(2):167–175. doi: 10.1136/jcp.36.2.167. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Pandolfi F., Semenzato G., de Rossi G., Quinti I., Guglielmi C., Pezzutto A., Lopez M., Tonietti G., Fontana L., Abo T. HNK-1 monoclonal antibody (Leu-7) in the identification of abnormal expansions of large granular lymphocytes. Clin Exp Immunol. 1983 Jun;52(3):641–647. [PMC free article] [PubMed] [Google Scholar]
  21. Pinkus G. S., Said J. W. Hodgkin's disease, lymphocyte predominance type, nodular--a distinct entity? Unique staining profile for L&H variants of Reed-Sternberg cells defined by monoclonal antibodies to leukocyte common antigen, granulocyte-specific antigen, and B-cell-specific antigen. Am J Pathol. 1985 Jan;118(1):1–6. [PMC free article] [PubMed] [Google Scholar]
  22. Quinti I., Pacilli L., Zoli V., De Sanctis G., Mannella E., Bonomo G., De Laurenzi A., Pandolfi F. Unusual phenotype (Leu 7+, OKT4+, OKM1+) expressed by cells from a patient with an abnormal expansion of granular lymphocytes. Acta Haematol. 1984;71(5):310–315. doi: 10.1159/000206607. [DOI] [PubMed] [Google Scholar]
  23. Raff H. V., Picker L. J., Stobo J. D. Macrophage heterogeneity in man. A subpopulation of HLA-DR-bearing macrophages required for antigen-induced T cell activation also contains stimulators for autologous-reactive T cells. J Exp Med. 1980 Sep 1;152(3):581–593. doi: 10.1084/jem.152.3.581. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Reinherz E. L., Kung P. C., Goldstein G., Levey R. H., Schlossman S. F. Discrete stages of human intrathymic differentiation: analysis of normal thymocytes and leukemic lymphoblasts of T-cell lineage. Proc Natl Acad Sci U S A. 1980 Mar;77(3):1588–1592. doi: 10.1073/pnas.77.3.1588. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Reinherz E. L., Kung P. C., Goldstein G., Schlossman S. F. A monoclonal antibody reactive with the human cytotoxic/suppressor T cell subset previously defined by a heteroantiserum termed TH2. J Immunol. 1980 Mar;124(3):1301–1307. [PubMed] [Google Scholar]
  26. Salter D. M., Krajewski A. S., Dewar A. E. Immunohistochemical staining of non-Hodgkin's lymphoma with monoclonal antibodies specific for the leucocyte common antigen. J Pathol. 1985 Aug;146(4):345–353. doi: 10.1002/path.1711460408. [DOI] [PubMed] [Google Scholar]
  27. Stein H., Gerdes J., Schwab U., Lemke H., Mason D. Y., Ziegler A., Schienle W., Diehl V. Identification of Hodgkin and Sternberg-reed cells as a unique cell type derived from a newly-detected small-cell population. Int J Cancer. 1982 Oct 15;30(4):445–459. doi: 10.1002/ijc.2910300411. [DOI] [PubMed] [Google Scholar]
  28. Stein H., Lennert K., Feller A. C., Mason D. Y. Immunohistological analysis of human lymphoma: correlation of histological and immunological categories. Adv Cancer Res. 1984;42:67–147. doi: 10.1016/s0065-230x(08)60456-x. [DOI] [PubMed] [Google Scholar]
  29. Stein H., Lennert K., Mason D. Y., Liangru S., Ziegler A. Immature sinus histiocytes. Their identification as a novel B-cell population. Am J Pathol. 1984 Oct;117(1):44–52. [PMC free article] [PubMed] [Google Scholar]
  30. Turner R. R., Wood G. S., Beckstead J. H., Colby T. V., Horning S. J., Warnke R. A. Histiocytic malignancies. Morphologic, immunologic, and enzymatic heterogeneity. Am J Surg Pathol. 1984 Jul;8(7):485–500. [PubMed] [Google Scholar]
  31. Verbi W., Greaves M. F., Schneider C., Koubek K., Janossy G., Stein H., Kung P., Goldstein G. Monoclonal antibodies OKT 11 and OKT 11A have pan-T reactivity and block sheep erythrocyte "receptors". Eur J Immunol. 1982 Jan;12(1):81–86. doi: 10.1002/eji.1830120115. [DOI] [PubMed] [Google Scholar]
  32. Warnke R. A., Gatter K. C., Falini B., Hildreth P., Woolston R. E., Pulford K., Cordell J. L., Cohen B., De Wolf-Peeters C., Mason D. Y. Diagnosis of human lymphoma with monoclonal antileukocyte antibodies. N Engl J Med. 1983 Nov 24;309(21):1275–1281. doi: 10.1056/NEJM198311243092102. [DOI] [PubMed] [Google Scholar]
  33. Wood G. S., Warner N. L., Warnke R. A. Anti-Leu-3/T4 antibodies react with cells of monocyte/macrophage and Langerhans lineage. J Immunol. 1983 Jul;131(1):212–216. [PubMed] [Google Scholar]

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