Table II.

Experimental groups, treatment summary and efficacy.

	Treatment description	Mice per group	Thermal dose?	Days to 3×	SD	Treatment ratio (versus no treatment)
mNP + CDDP + AMF	CDDP 1 h before AMF exposure. mNP injected immediately before activation. Treated to CEM60 at centre of tumour	7	Yes	36	2.4	2.6
mNP + AMF	mNP injected immediately before activation. Treated to CEM60 at centre of tumour	6	Yes	21	4.5	1.5
CDDP alone	CDDP given with no additional treatment/treatment controls	4	No	25	7.1	1.8
CDDP + AMF	CDDP 1 h before AMF exposure. PBS injected at the same volume as prescribed mNP for other groups. Thermal probes inserted and exposed to AMF for 30 min	4	No	25	6.3	1.8
CDDP + mNP	CDDP 1 h before mNP injection. Animal under anesthesia with body temperature maintained for 30 min after mNP injection	6	No	27	7.0	2.0
AMF	PBS injected at the same volume as prescribed mNP for other groups. Thermal probes inserted and exposed to AMF for 30 min	5	No	14	4.0	1.0
No treatment	No treatments/treatment controls	6	No	14	4.3	1.0