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. 2016 Aug 24;3:16056. doi: 10.1038/mtm.2016.56

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Copyright © 2016 Official journal of the American Society of Gene & Cell Therapy

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Generation of self-complementary adeno-associated virus 2 (scAAV2) to deliver constitutively active Rap1a (CARap1a) driven by an RPE65 promoter to retinal pigment epithelial (RPE) cells. (a) Diagrams of the scAAV2 containing the RPE cell-specific RPE65 promoter driving GFP (control vector scAAV2-RPE65-GFP) or CARap1a (scAAV2-RPE65-CARap1a-GFP); (b) images taken under fluorescent microcopy showing GFP expression in a cell line of human RPE cells, ARPE-19, but not in human retinal microvascular endothelial cells (hRMVECs), each transfected with plasmid DNA of scAAV2-RPE65-GFP or scAAV2-RPE65-CARap1a-GFP.